Immunohistochemical Analysis of Programmed Death-Ligand 1 Expression in Equine Sarcoids
نویسندگان
چکیده
The aim of the study was to assess expression immune checkpoint inhibitor programmed death-ligand 1 (PD-L1) in equine sarcoids (ES). Programmed is expressed by various cancer cells block T cell–mediated elimination tumor cells. Antibodies targeting human PD-L1 were tested immunohistochemistry for their cross-reactivity with using formalin-fixed, paraffin-embedded tissues. Our results do not support an important role PD-L1-mediated evasion ES disease and hence offer a rationale anti-PD-1/PD-L1-based immunotherapy against ES.
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ژورنال
عنوان ژورنال: Journal of Equine Veterinary Science
سال: 2021
ISSN: ['1542-7412', '0737-0806']
DOI: https://doi.org/10.1016/j.jevs.2020.103338